Adobe After Effects CC and CS6 require updates to be compatible.
Download the latest build for After Effects CC (12.0.1) HERE.
Yes, in some instances, the Adobe Creative Cloud desktop application may encounter an “incompatible software error” and requires a workaround to be compatible. For the latest information visit: http://helpx.adobe.com/creative-cloud/kb/incompatible-software-mavericks.html
Adobe Flash Player may require you to remove sandbox restrictions from your Apple Safari player. Learn more at: http://helpx.adobe.com/flash-player/kb/removing-sandbox-restrictions-your-safari.html
Safari 7 may block the first attempt to view a PDF using Adobe Reader. Get the workaround at: http://helpx.adobe.com/acrobat/kb/blocked-plugin-alert-safari-7.html
Customers are encouraged to check plug-in compatibility by contacting the plug-in vendor before upgrading to Mac OS 10.9. For third-party products, contact the manufacturer for guidance.
Are the trial versions of CC and CS6 and applications compatible with Mac OS 10.9?
Yes. If a full version of a CC or CS6 product is compatible with Mac OS 10.9, then the trial version of that product is compatible as well. If there are any known issues described in this document, they also apply to the trial versions.